The six populations included: Mound, Ohio, workers exposed to polonium, tritium and plutonium nuclear power plant workers within the Landauer dosimetry and Nuclear Regulatory Commission data files industrial radiographers Mallinckrodt uranium workers uranium workers who linked with the US Renal Data System and nuclear weapons test participants. ![]() radiation workers and veterans, this project had a total of nine specific aims which included studies of six populations for multiple endpoints including cancer overall mortality, leukemia and non-cancer mortality. Within the overall goal of the epidemiologic study of one million U.S. The cost-efficient study builds on the investments made and foundations laid by investigators and government agencies over the past 30-40 years, which have established early worker cohorts that can now provide answers to questions on the lifetime human health risks more » associated with low-level radiation exposures. radiation workers and veterans has been designed to provide information on risk following chronic exposures by focusing on occupational groups with differing radiation exposure patterns, including intakes of radionuclides. The single most important question in radiation epidemiology is determining the level of health risks associated with radiation exposures that occur gradually over time. They should lay a strong scientific foundation for accelerated translation of scientific discoveries into individual and population health benefits. These recommendations can transform cancer epidemiology and the field of epidemiology, in general, by enhancing transparency, interdisciplinary collaboration, and strategic applications of new technologies. The themes are (i) extending the reach of epidemiology beyond discovery and etiologic research to include multilevel analysis, intervention evaluation, implementation, and outcomes research (ii) transforming the practice of epidemiology by moving toward more access and sharing of protocols, data, metadata, and specimens to foster collaboration, to ensure reproducibility and replication, and accelerate more » translation (iii) expanding cohort studies to collect exposure, clinical, and other information across the life course and examining multiple health-related endpoints (iv) developing and validating reliable methods and technologies to quantify exposures and outcomes on a massive scale, and to assess concomitantly the role of multiple factors in complex diseases (v) integrating big data science into the practice of epidemiology (vi) expanding knowledge integration to drive research, policy, and practice (vii) transforming training of 21st century epidemiologists to address interdisciplinary and translational research and (viii) optimizing the use of resources and infrastructure for epidemiologic studies. Eight overarching thematic recommendations, with proposed corresponding actions for consideration by funding agencies, professional societies, and the research community emerged from the collective intellectual discourse. N 2012, the National Cancer Institute (NCI) engaged the scientific community to provide a vision for cancer epidemiology in the 21st century. (ORNL), Oak Ridge, TN (United States) Sponsoring Org.: USDOE OSTI Identifier: 1845780 Grant/Contract Number: AC05-00OR22725 Resource Type: Accepted Manuscript Journal Name: International Journal of Radiation Biology Additional Journal Information: Journal Volume: 98 Journal Issue: 4 Journal ID: ISSN 0955-3002 Publisher: Taylor and Francis Country of Publication: United States Language: English Subject: 63 RADIATION, THERMAL, AND OTHER ENVIRON. Publication Date: Research Org.: Oak Ridge National Lab. Landauer, Inc., Glenwood, IL (United States).Washington State Univ., Richland, WA (United States).Risk Assessment Corporation, Neeses, SC (United States).Vanderbilt Univ., Nashville, TN (United States) International Epidemiology Institute, Rockville, MD (United States). Francis Marion University, Florence, SC (United States) Oak Ridge National Lab.National Council on Radiation Protection and Measurements, Inc., Bethesda, MD (United States) Harvard Medical School, Boston, MA (United States).Oak Ridge Associated Univ., Oak Ridge, TN (United States).ToxStrategies, Inc., Cary, NC (United States).Radian Scientific, LLC, Hunstville, AL (United States).NASA Langley Research Center, Hampton, VA (United States).Defense Threat Reduction Agency, VA (United States).Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States).US Department of Energy (USDOE), Gaithersburg, MD (United States). ![]()
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